Why is Rubber Stopper For Blood Collection Better?

What is vacuum blood collection specimen container?

Vacuum blood collection container is a device used for drawing and collecting blood from a vein by venipuncture, usually for medical or laboratory test and analysis.

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Main components for vacuum blood collection tube include: transparent or plastic tube, plastic cap,  rubber stopper and specific additives for different testing purpose. Among all components, stopper is the only part made from rubber by vulcanization machine.

About Rubber Stopper for Blood Collection Vacutainer

It’s compression moulded rubber products from vulcanization machine. It’s made of bromobutyl rubber material which has fantastic self-sealing performance and chemical resistance performance.

Rubber stopper creates a vacuum space inside container to prevent liquids or gases from escaping from vacuum tube, meanwhile preventing contaminants from entering vacutainer which may cause pollution to specimen and affecting testing results.

How to choose a suitable rubber stopper for blood collection tube?

A suitable rubber stopper(see product details) should meet certain standards of physical performance, chemical performance and biological performance.

Physical Performance

• Stopper Size: upper diameter and lower diameter should be within certian tolerance, thickness of stopper should be designed within certain range.
• Appearance: stopper should have flat surface and consistent color.
• Needle Puncture and Pulling Force: within certain range.
• Puncture Crumbs: within certain range.

Chemical Performance

• The performance of ultraviolet absorption, oxidiable substances, conductivity, PH change rate and heavy metal content should meet certain ISO standard.

Biological Performance

• Hemolysis rate should be up to ISO standard.

For more details of butyl rubber stopper plug for blood collection vacutainer, please send inquiry via

In the evolving world of clinical diagnostics and laboratory testing, precision and reliability in blood sample collection are paramount. Enter the Rubber Red Top 10mL Glass Serum Tube with Clot Activator—a sophisticated solution designed to streamline blood sample collection and enhance the quality of diagnostic results. In this blog, we delve into the features, benefits, and innovations associated with this essential laboratory tool.

What Is the Rubber Red Top 10mL Glass Serum Tube?

The Rubber Red Top 10mL Glass Serum Tube is a specialized blood collection device used in medical and laboratory settings to collect, separate, and prepare serum samples for analysis. The "Red Top" designation refers to the color of the rubber stopper, which indicates that the tube contains a clot activator—a substance that promotes rapid clotting of the blood, facilitating the separation of serum from cellular components.

Key Components:

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• Glass Tube: Provides a sterile and chemically inert environment, minimizing contamination and ensuring the purity of the collected serum.
• Rubber Red Top: Easily identifiable, indicating the presence of a clot activator.
• Clot Activator: Accelerates the blood clotting process, making it easier to obtain high-quality serum for testing.

How Does It Work?

The functionality of the Rubber Red Top 10mL Glass Serum Tube hinges on its clot activator, which is typically a silica-based additive. Here’s a step-by-step look at the process:

1. Blood Collection: Blood is drawn from the patient into the tube through a needle, creating a vacuum that ensures the correct volume of blood is collected.
2. Clot Activation: The clot activator initiates the clotting process, transforming the liquid blood into a gel-like clot.
3. Centrifugation: The tube is then placed in a centrifuge, which spins at high speed, separating the serum from the clotted blood.
4. Serum Extraction: The clear, yellowish serum is extracted from the top of the tube and can be used for various diagnostic tests.

Advantages of the Rubber Red Top 10mL Glass Serum Tube

1. Rapid Clotting: The clot activator ensures that blood clots quickly, reducing the time needed for serum preparation and speeding up the overall diagnostic process.
2. High-Quality Serum: Glass tubes are non-reactive and provide a stable environment for the blood, minimizing the risk of contamination and preserving the integrity of the serum.
3. Ease of Use: The red rubber top is easily identifiable, allowing healthcare professionals to quickly select the appropriate tube for serum collection.
4. Versatility: Suitable for a wide range of diagnostic tests, including chemistry, immunology, and serology, making it a versatile tool in clinical laboratories.
5. Reduced Risk of Hemolysis: The glass material and gentle clot activation process minimize the risk of hemolysis (breakdown of red blood cells), which can interfere with test results.

Applications in Clinical Practice

The Rubber Red Top 10mL Glass Serum Tube is used in various clinical and diagnostic settings, including:

• Routine Blood Tests: Used for standard diagnostic blood tests that require serum, such as liver function tests, kidney function tests, and lipid profiles.
• Immunoassays: Essential for tests that measure the levels of hormones, proteins, and antibodies in the blood.
• Specialized Testing: Used in more specialized testing, such as detecting biomarkers for diseases and conditions.

Innovations and Future Directions

Advancements in blood collection technology have led to continuous improvements in serum tubes. Here are some innovations and future directions:

1. Improved Clot Activators: Ongoing research aims to develop clot activators that work even faster and more efficiently, further reducing the time needed for serum preparation.
2. Enhanced Tube Materials: New materials and coatings are being explored to make glass tubes even more reliable and reduce any potential interactions with blood components.
3. Automation Integration: Future serum tubes may be designed to integrate seamlessly with automated blood collection and analysis systems, increasing efficiency in high-throughput laboratories.
4. Environmental Considerations: Innovations in eco-friendly materials and recycling programs are being considered to reduce the environmental impact of disposable blood collection tubes.

The Rubber Red Top 10mL Glass Serum Tube with Clot Activator represents a crucial innovation in blood collection, offering rapid clotting, high-quality serum separation, and ease of use. Its role in clinical diagnostics underscores the importance of reliable tools in obtaining accurate test results and improving patient care. As technology continues to evolve, we can anticipate even more advancements in blood collection methods, further enhancing the efficiency and effectiveness of diagnostic testing.

By understanding and utilizing these innovations, healthcare professionals can ensure better outcomes for patients and contribute to the ongoing progress in medical diagnostics.

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